Methotrexate Side Effects: Review Article

Methotrexate Side Effects: Review Article

Side effects of MTX high dose (MTX-HD) may be life threatening, however those of various doses of oral MTX are variable because of the interindividual variability of gastrointestinal absorption of this drug. Bone marrow, gastrointestinal mucosa and hair are particularly vulnerable to the effects of MTX, secondary to their high rate of cellular turnover [2] and because MTX concentration is inver...

Rare side effects of subcutaneous methotrexate therapy.

Side effects and management of side effects of methotrexate in rheumatoid arthritis.

Low-dose methotrexate (MTX) remains the first-line treatment option among the disease-modifying antirheumatic drugs in patients with rheumatoid arthritis. However, diverse side effects are the major reason for MTX withdrawal and change of treatment. The following article reviews the published data on general and organ-specific side effects and outlines the current recommendations addressing pre...

Cardiovascular effects of fingolimod: A review article

Multiple sclerosis (MS) is a chronic auto-immune disease. Most therapeutic strategies for treatment of this disease direct immune modulation and control of inflammatory processes. First-line therapeutic agents showed moderate efficacy and frequent side-effects with moderate efficacy in trials. Their parental administration and limited long-term adherence restrict their efficacy compared with se...

Review Article: Ocular Effects of Sulfur Mustard

Purpose: To review current knowledge about ocular effects of sulfur mustard (SM) and the associated histopathologic findings and clinical manifestations Methods: Literature review of medical articles (human and animal studies) was accomplished using PubMed, Scopus and ISI databases. A total of 274 relevant articles in English were retrieved and reviewed thoroughly. Results: Eyes are the most se...